Calcitonin generelated peptidemediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review).
Mol Med Rep
; 23(1)2021 01.
Article
en En
| MEDLINE
| ID: mdl-33179114
ABSTRACT
Calcitonin generelated peptide (CGRP) is the predominant neurotransmitter located in sensory nerves. This peptide is extensively distributed in central and peripheral tissues. CGRP causes relaxation of cardiovascular smooth muscle cells and confers protection against ischaemic myocardium and cardiac remodeling. The pharmacological effects of nitroglycerine and rutaecarpine have been demonstrated to be associated with an increase in the synthesis and release of CGRP. In the gastrointestinal tissues, CGRP participates in the regulation of gastrointestinal function, and exerts protective effects on gastric mucosa. Rutaecarpine, capsaicin and its derivatives, such as evodiamine, decrease gastric mucosal damage induced by several factors, including increased synthesis and release of CGRP. Taken together, this review focuses on the pharmacological effects of several CGRP related canonical drugs and suggests that synthesis and secretion of CGRP exhibit significant therapeutic effects in the occurrence and development of cardiovascular and gastrointestinal diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Enfermedades Cardiovasculares
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Péptido Relacionado con Gen de Calcitonina
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Nitroglicerina
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Alcaloides Indólicos
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Enfermedades Gastrointestinales
Límite:
Humans
Idioma:
En
Revista:
Mol Med Rep
Año:
2021
Tipo del documento:
Article