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GHR signalling: Receptor activation and degradation mechanisms.
Chhabra, Yash; Lee, Christine M M; Müller, Alexandra Franziska; Brooks, Andrew J.
Afiliación
  • Chhabra Y; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231, USA.
  • Lee CMM; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
  • Müller AF; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia.
  • Brooks AJ; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia. Electronic address: a.brooks@uq.edu.au.
Mol Cell Endocrinol ; 520: 111075, 2021 01 15.
Article en En | MEDLINE | ID: mdl-33181235
Growth hormone (GH) actions via initiating cell signalling through the GH receptor (GHR) are important for many physiological processes, in addition to its well-known role in regulating growth. The activation of JAK-STAT signalling by GH is well characterized, however knowledge on GH activation of SRC family kinases (SFKs) is still limited. In this review we summarise the collective knowledge on the activation, regulation, and downstream signalling of GHR. We highlight studies on GH activation of SFKs and the important outcome of this signalling pathway with a focus on the different degradation mechanisms that can regulate GHR availability since this is an area that warrants further study considering its role in tumour progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Somatotropina / Transducción de Señal / Proteolisis Límite: Animals / Humans Idioma: En Revista: Mol Cell Endocrinol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Somatotropina / Transducción de Señal / Proteolisis Límite: Animals / Humans Idioma: En Revista: Mol Cell Endocrinol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda