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Prevalence of hepatitis B among childbearing women and infant born to HBV-positive mothers in Togo.
Ekouevi, Didier K; Larrouy, Lucile; Gbeasor-Komlanvi, Fifonsi A; Mackiewicz, Vincent; Tchankoni, Martin K; Bitty-Anderson, Alexandra M; Gnatou, Gatibe Yendu-Suglpak; Sadio, Arnold; Salou, Mounerou; Dagnra, Claver A; Descamps, Diane; Coffie, Patrick A.
Afiliación
  • Ekouevi DK; Département de Santé Publique, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo. didier.ekouevi@gmail.com.
  • Larrouy L; Institut de Santé Publique Epidémiologie Développement (ISPED), Université de Bordeaux, Bordeaux, France. didier.ekouevi@gmail.com.
  • Gbeasor-Komlanvi FA; Programme PACCI - Site ANRS Côte d'Ivoire, CHU de Treichville, Abidjan, Côte d'Ivoire. didier.ekouevi@gmail.com.
  • Mackiewicz V; INSERM U1219 Bordeaux Population Health Research, ISPED, Université de Bordeaux, Bordeaux, France. didier.ekouevi@gmail.com.
  • Tchankoni MK; Centre Africain de Recherche en Epidémiologie et en Santé Publique (CARESP), Lomé, Togo. didier.ekouevi@gmail.com.
  • Bitty-Anderson AM; Université de Paris, INSERM UMR 1137 IAME, F-75018, Paris, France.
  • Gnatou GY; Laboratoire de Virologie, AP-HP, Hôpital Bichat-Claude Bernard, F-75018, Paris, France.
  • Sadio A; Département de Santé Publique, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo.
  • Salou M; Centre Africain de Recherche en Epidémiologie et en Santé Publique (CARESP), Lomé, Togo.
  • Dagnra CA; Laboratoire de Virologie, AP-HP, Hôpital Bichat-Claude Bernard, F-75018, Paris, France.
  • Descamps D; Centre Africain de Recherche en Epidémiologie et en Santé Publique (CARESP), Lomé, Togo.
  • Coffie PA; Programme PACCI - Site ANRS Côte d'Ivoire, CHU de Treichville, Abidjan, Côte d'Ivoire.
BMC Infect Dis ; 20(1): 839, 2020 Nov 12.
Artículo en Inglés | MEDLINE | ID: mdl-33183254
ABSTRACT

BACKGROUND:

Hepatitis B virus (HBV) infection is a public health problem in Togo and transmission to the child occurs mainly during childbirth. The objective of this study was to estimate the prevalence of HBV among childbearing women and infants born to HBV positive mothers in Togo.

METHODS:

A national cross-sectional study was carried out in six cities in Togo in the six health regions in Togo. Mother-child pairs were recruited from immunization centers or pediatric wards in Lomé, Tsévié, Atakpamé, Sokodé, Kara and Dapaong in 2017. Women aged 18 and over with one child of at least 6 months old were included. A standardized questionnaire was used for data collection and HBV screening was performed using Determine® rapid tests. The prevalence of HBV, defined by a positive HBV surface antigen (HBsAg), was estimated in mothers and then in infants of mothers who were positive for HBsAg. Logistic regression model was performed to identify risk factors for HBsAg positivity in mothers.

RESULTS:

A total of 2105 mothers-pairs child were recruited. The median age of mothers and infants was 29 years, interquartile range (IQR) [25-33] and 2.1 years, IQR [1-3] respectively. About 35% of women were screened for HBV during antenatal care and 85% of infants received three doses of HBV immunization. Among mothers, the prevalence of HBV was 10.6, 95% confidence interval (95% CI) [9.4-12.0%], and 177 had detectable HBV viral load (> 10 IU/mL). Among mothers with positive HBsAg, three infants also had positive HBsAg, a prevalence of 1.3, 95% CI [0.2-3.8%]. In multivariable analysis, HIV-infection (aOR = 2.19; p = 0.018), having at least three pregnancies (aOR = 1.46; p = 0.025) and living in Tsévié (aOR = 0.31; p < 0.001) compared to those living in Lomé, were associated to HBV infection in mothers.

CONCLUSION:

In this study, one out of 10 childbearing women were infected with HBV, but less than 2% of infant born to HBV positive mothers under 5 years' old who received immunization under the Expanded Program on Immunization were infected. Improving antenatal screening and providing targeted interventions in babies could help eliminate HBV in Togo.
Asunto(s)
Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar Tema en salud: Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Virus de la Hepatitis B / Vacunación / Transmisión Vertical de Enfermedad Infecciosa / Hepatitis B Tipo de estudio: Ensayo clínico controlado / Estudio diagnóstico / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Niño, preescolar / Femenino / Humanos / Lactante / Masculino / Embarazo / Joven adulto País/Región como asunto: Africa Idioma: Inglés Revista: BMC Infect Dis Asunto de la revista: Enfermedades Transmisibles Año: 2020 Tipo del documento: Artículo País de afiliación: Togo

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Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar Tema en salud: Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Virus de la Hepatitis B / Vacunación / Transmisión Vertical de Enfermedad Infecciosa / Hepatitis B Tipo de estudio: Ensayo clínico controlado / Estudio diagnóstico / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Adulto / Niño, preescolar / Femenino / Humanos / Lactante / Masculino / Embarazo / Joven adulto País/Región como asunto: Africa Idioma: Inglés Revista: BMC Infect Dis Asunto de la revista: Enfermedades Transmisibles Año: 2020 Tipo del documento: Artículo País de afiliación: Togo
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