Hierarchically Molecular Imprinted Porous Particles for Biomimetic Kidney Cleaning.
Adv Mater
; 32(52): e2005394, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-33184956
ABSTRACT
Blood purification by adsorption of excessive biomolecules is vital for maintaining human health. Here, inspired by kidney self-purification, which removes a number of biomolecules with different sizes simultaneously, hierarchical molecular-imprinted inverse opal particles integrated with a herringbone microfluidic chip for efficient biomolecules cleaning are presented. The particle possesses combinative porous structure with both surface and interior imprints for the specific recognition of small molecules and biomacromolecules. Additionally, the presence of the herringbone mixer largely improve the adsorption efficiency due to enhanced mixing. Moreover, the inverse opal framework of the particles give rise to optical sensing ability for self-reporting of the adsorption states. These features, together with its reusability, biosafety, and biocompatibility, make the platform highly promising for clinical blood purification and artificial kidney construction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomimética
/
Impresión Molecular
/
Riñón
Idioma:
En
Revista:
Adv Mater
Asunto de la revista:
BIOFISICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China