A "hit-and-run" affair - A possible link for cancer progression in virally driven cancers.
Biochim Biophys Acta Rev Cancer
; 1875(1): 188476, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33186643
ABSTRACT
BACKGROUND:
It is well-known that certain cancers are caused by viruses. However, viral oncogenesis is complex and only a small fraction of the infected people develop cancer. Indeed, a number of environmental factors can contribute to virally infected cells developing cancer hallmarks, promoting tumorigenesis. SCOPE OF REVIEW The hit-and-run theory proposes that viruses facilitate the accumulation of mutations and promote genomic instability until the virus becomes dispensable for tumour maintenance. Indeed, several studies have reported viral genome, episome and/or oncogene loss in tumour cells without losing malignant phenotype. MAJORCONCLUSIONS:
The current evidence supports the clear contribution of certain viruses to develop cancers. Importantly, the evidence supporting the sustained maintenance of malignancy after the loss of viral "presence" is sufficient to support the hit-and-run hypothesis of viral cancer development. Long-term tracking of vaccination outcome over the decades will test this theory. GENERALSIGNIFICANCE:
If the hit-and-run theory is true, viruses might cause more cancers than previously thought and will have implications in the prevention of many cancers through implementing vaccination programs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Virus Oncogénicos
/
Transformación Celular Neoplásica
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia