Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Chem Commun (Camb)
; 56(96): 15137-15140, 2020 Dec 08.
Article
en En
| MEDLINE
| ID: mdl-33211039
ABSTRACT
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mucina-1
/
Vacunas contra el Cáncer
/
Lectinas
/
Anticuerpos Monoclonales
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
España
