Response to Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
Science
; 370(6519)2020 11 20.
Article
en En
| MEDLINE
| ID: mdl-33214247
ABSTRACT
Park et al question one out of seven findings from Hadzipasic et al whether TPX2 allosterically regulates the oldest Aurora. We had already addressed the two concerns raised-sparse sequence sampling and not forcing the gene to the species tree-before publication. Moreover, we believe their ancestral sequence reconstruction would be consistent with a nonallosteric common ancestor, and we show large sequence differences caused by species tree-enforced gene trees.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Ciclo Celular
/
Proteínas Asociadas a Microtúbulos
Idioma:
En
Revista:
Science
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos