Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment.

Quignot, Nadia; Wiecek, Witold; Lautz, Leonie; Dorne, Jean-Lou; Amzal, Billy

Quignot, Nadia; Wiecek, Witold; Lautz, Leonie; Dorne, Jean-Lou; Amzal, Billy.

Afiliación

Quignot N; CERTARA, Paris, France. Electronic address: nadia.quignot@certara.com.
Wiecek W; CERTARA, London, UK. Electronic address: witold.wiecek@certara.com.
Lautz L; Risk Assessment Department, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Maisons-Alfort, France.
Dorne JL; European Food Safety Authority, Via Carlo Magno 1A, 43126, Parma, Italy.
Amzal B; CERTARA, Paris, France.

Toxicol Lett ; 337: 111-120, 2021 Feb 01.

Article en En | MEDLINE | ID: mdl-33232775

Asunto(s)

Citocromo P-450 CYP2C19/metabolismo; Citocromo P-450 CYP2C9/metabolismo; Toxicocinética; Algoritmos; Área Bajo la Curva; Teorema de Bayes; Simulación por Computador; Citocromo P-450 CYP2C19/genética; Citocromo P-450 CYP2C9/genética; Variación Genética; Humanos; Cinética; Fenotipo; Polimorfismo Genético; Medición de Riesgo; Xenobióticos/metabolismo

Palabras clave

CYP2C19; CYP2C9; Inter-individual variability; Polymorphic pathways; Risk assessment; Uncertainty factors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocromo P-450 CYP2C9 / Citocromo P-450 CYP2C19 / Toxicocinética Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Toxicol Lett Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

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