[Clinical effectiveness of an immunomodulatory drug based on a muramylpeptide composition in the treatment of patients with chronic generalized periodontitis]. / Klinicheskaya effektivnost' immunomoduliruyushchego preparata na osnove kompozitsii muramilpeptidov pri lechenii patsientov s khronicheskim generalizovannym parodontitom.

ABSTRACT

THE AIM OF THE STUDY To assess the efficacy of an immunomodulatory drug based on a muramylpeptide composition in the treatment of patients with chronic generalized periodontitis. MATERIALS AND METHODS: The study comprised 40 patients with chronic generalized periodontitis. In controls the treatment consisted in oral hygiene instructions, professional oral hygiene procedures and root scalling while in main study group the conventional treatment protocol was combined with intramuscular injections of muramylpeptide composition. RESULTS: The study showed significant reduction of inflammatory symptoms in periodontal tissues in muramylpeptide composition group. CONCLUSION: Muramylpeptide composition increases the threshold of tissue protection against constantly present microbial accumulations in periodontal disease patients thus providing opportunity for excluding toxic antimicrobial agents and/or antibiotics (or reducing their dosages).