Diagnostic performance of LI-RADS for MRI and CT detection of HCC: A systematic review and diagnostic meta-analysis.
Eur J Radiol
; 134: 109404, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33276248
ABSTRACT
PURPOSE:
To perform a meta-analysis evaluating the diagnostic accuracy of the Liver Imaging Reporting and Data System (LI-RADS) category ≥ 3 (LI-RADS 3-5v) for detecting hepatocellular carcinoma (HCC).METHOD:
A systematic PubMed, Embase, and Web of Science electronic database search was performed for original diagnostic studies published through July 31, 2018. Statistical analysis included data pooling, forest plot construction, heterogeneity testing, meta-regression, and subgroup analyses.RESULTS:
Eighteen studies (v2011, v2014 and v2017) involving 3386 patients were included in the meta-analysis. The pooled sensitivity and specificity of LI-RADS ≥ 3 for diagnosing HCC were 0.86 (95 % confidence interval (CI) 0.78-0.91) and 0.85 (95 % CI 0.78-0.90), respectively. The area under the curve (AUC) was 0.92 (95 % CI 0.89-0.94). Meta-regression analysis showed that the publication year, blinding to the reference standard and the number of readers were significant factors affecting heterogeneity. In subgroup analyses, magnetic resonance imaging (MRI) demonstrated higher sensitivity (0.82 vs. 0.73) and comparable specificity (0.79 vs. 0.78) than computed tomography (CT). For HCCs ≤30â¯mm, LI-RADS showed lower sensitivity of 0.72 and specificity of 0.80 compared with HCC of all sizes. LR-5 showed higher sensitivity and specificity than LR-3 (sensitivity 0.67 vs. 0.07, Pâ¯=â¯0.02; specificity 0.93 vs. 0.75, pâ¯<â¯0.001) and higher sensitivity than LR-4 (sensitivity 0.67 vs. 0.29, Pâ¯=â¯0.02; specificity 0.93 vs. 0.80, pâ¯=â¯0.75). LRâ¯≥â¯5 had higher specificity at the cost of decreased sensitivity than LRâ¯≥â¯3 (specificity 0.94 vs. 0.68, pâ¯<â¯0.001; sensitivity 0.66 vs. 0.74, Pâ¯=â¯0.70) and LRâ¯≥â¯4 (specificity 0.94 vs. 0.84, pâ¯<â¯0.001; sensitivity 0.66 vs. 0.74, Pâ¯=â¯0.77).CONCLUSIONS:
LI-RADS ≥ 3 shows high diagnostic accuracy for HCCs, with a pooled sensitivity of 0.86 and specificity of 0.85. The specificity is higher for LR-5 and LRâ¯≥â¯5. However, further prospective studies on LI-RADS ≥ 3 are needed to elucidate its value for diagnosing small HCCs (≤20â¯mm).Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
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Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Eur J Radiol
Año:
2021
Tipo del documento:
Article