Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients.
Transpl Infect Dis
; 23(3): e13542, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-33278052
ABSTRACT
Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridonas
/
Triazinas
/
Morfolinas
/
Dibenzotiepinas
/
Gripe Humana
Límite:
Humans
Idioma:
En
Revista:
Transpl Infect Dis
Asunto de la revista:
TRANSPLANTE
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos