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Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?
Lotz, Christopher; Muellenbach, Ralf M; Meybohm, Patrick; Mutlak, Haitham; Lepper, Philipp M; Rolfes, Caroline-Barbara; Peivandi, Asghar; Stumpner, Jan; Kredel, Markus; Kranke, Peter; Torje, Iuliu; Reyher, Christian.
Afiliación
  • Lotz C; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Muellenbach RM; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Meybohm P; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Mutlak H; Department of Anaesthesiology, Intensive Care and Emergency Medicine, Sana Klinikum Offenbach, Kassel, Germany.
  • Lepper PM; Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
  • Rolfes CB; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Peivandi A; Department of Cardiovascular Surgery, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Stumpner J; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Kredel M; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Kranke P; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Torje I; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Reyher C; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
Acta Anaesthesiol Scand ; 65(5): 629-632, 2021 05.
Article en En | MEDLINE | ID: mdl-33296498
ABSTRACT

BACKGROUND:

Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation.

METHODS:

We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20 ppm iNO for 15-30 minutes.

RESULTS:

The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed.

CONCLUSION:

Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19-induced moderate to severe ARDS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 / Óxido Nítrico Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 / Óxido Nítrico Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Año: 2021 Tipo del documento: Article País de afiliación: Alemania