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Six novel lignanoids with complex structures from Sigesbeckia glabrescens Makino with their cytotoxic activities.
Gao, Xiao-Xu; Gao, Yu-Ning; Wang, Dong-Dong; Hu, Gao-Sheng; Yan, Ting; Jia, Jing-Ming; Wang, An-Hua.
Afiliación
  • Gao XX; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Gao YN; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Wang DD; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Hu GS; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Yan T; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Jia JM; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • Wang AH; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: sywanganhua@163.com.
Fitoterapia ; 148: 104799, 2021 Jan.
Article en En | MEDLINE | ID: mdl-33301798
Six new lignanoids, Glalignin A-E (1-5) and Glaneolignin A (6), together with four analogues, (+)-isolariciresinol (7), (+)-syringaresinol (8), dihydrodehydrodiconiferyl alcohol (9) and tribulusamide A (10), were obtained from the aerial parts of Sigesbeckia glabrescens Makino and also isolated for the first time from the Sigesbeckia genus. The structures of these compounds were elucidated by the interpretation of HRESIMS, 1D NMR, 2D NMR data and chemical evidence. The cytotoxic activities of the compounds were evaluated by testing their inhibition in several tumor cells using the MTT assay. New compound 2 and 5 displayed cytotoxicity against the human cancer cell lines human lung adenocarcinoma cells (A549) with IC50 values of 32.89 ± 6.83 and 35.86 ± 6.83 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Asteraceae / Antineoplásicos Fitogénicos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Asteraceae / Antineoplásicos Fitogénicos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos