Your browser doesn't support javascript.
loading
Membrane vesicles nanotheranostic systems: sources, engineering methods, and challenges.
Nie, Weidong; Wu, Guanghao; Zhong, Haizheng; Xie, Hai-Yan.
Afiliación
  • Nie W; School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
  • Wu G; School of Life Science, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
  • Zhong H; School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
  • Xie HY; School of Life Science, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Biomed Mater ; 16(2): 022009, 2021 02 24.
Article en En | MEDLINE | ID: mdl-33307545
Extracellular vesicles (EVs) are cell secretory native components with long-circulation, good biocompatibility, and physiologic barriers cross ability. EVs derived from different donor cells inherit varying characteristics and functions from their original cells and are favorable to serve as vectors for diagnosing and treating various diseases. However, EVs nanotheranostics are still in their infancy because of their limited accumulation at lesion sites and compromised therapy efficiency. Hence, engineering modification of EVs is usually needed to further enhance their stability, biological activity, and lesion-targeting capacity. Herein, we overview the characteristics of EVs from different sources, as well as the latest developments of surface engineering and cargo loading methods. We also focus especially on advances in EVs-based disease theranostics. At the end of the review, we predict the obstacles and prospects of the future clinical application of EVs.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Sistemas de Liberación de Medicamentos / Ingeniería de Tejidos / Nanomedicina / Nanomedicina Teranóstica Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Sistemas de Liberación de Medicamentos / Ingeniería de Tejidos / Nanomedicina / Nanomedicina Teranóstica Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido