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A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.
Albulescu, Laura-Oana; Xie, Chunfang; Ainsworth, Stuart; Alsolaiss, Jaffer; Crittenden, Edouard; Dawson, Charlotte A; Softley, Rowan; Bartlett, Keirah E; Harrison, Robert A; Kool, Jeroen; Casewell, Nicholas R.
Afiliación
  • Albulescu LO; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Xie C; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.
  • Ainsworth S; Centre for Analytical Sciences Amsterdam (CASA), 1098 XH, Amsterdam, The Netherlands.
  • Alsolaiss J; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Crittenden E; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Dawson CA; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Softley R; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Bartlett KE; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Harrison RA; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Kool J; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
  • Casewell NR; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK.
Nat Commun ; 11(1): 6094, 2020 12 15.
Article en En | MEDLINE | ID: mdl-33323937
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mordeduras de Serpientes / Antivenenos Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America central / Asia Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mordeduras de Serpientes / Antivenenos Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America central / Asia Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido