Iron modulatory property of a polysaccharide from Indian medicinal plant Ocimum sanctum.
Free Radic Res
; 55(5): 510-519, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-33327808
ABSTRACT
Despite being an essential element for normal functioning of cells and organisms, iron, in excess, can induce oxidative stress by generating reactive oxygen species. A water-soluble, non-toxic iron chelator can reduce the iron-induced oxidative stress in the body as well as help in extricating excess iron. Herein, we report an Ocimum sanctum-derived antioxidant polysaccharide (OSP) that inhibits the deleterious effect of iron. Ocimum sanctum is a widely acknowledged medicinal plant contributing toward several biological benefits. Besides showing good hydroxyl radical scavenging activity, OSP could bind to ferric and ferrous ions to prevent their participation in redox reactions as revealed from modified 2-deoxyribose assays, carried out under various conditions. It also acted as an iron modulator to prevent site-specific damage and was effective in protecting mouse fibroblast L929 cells against iron induced death.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Extractos Vegetales
/
Ocimum sanctum
/
Hojas de la Planta
/
Sobrecarga de Hierro
/
Hierro
Límite:
Animals
Idioma:
En
Revista:
Free Radic Res
Asunto de la revista:
BIOQUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
India