Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice.
Neurobiol Stress
; 13: 100262, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-33344715
ABSTRACT
Acute physical or psychological stress can elicit adaptive behaviors that allow an organism maintain homeostasis. However, intense and/or prolonged stressors often have the opposite effect, resulting in maladaptive behaviors and curbing goal-directed action; in the extreme, this may contribute to the development of psychiatric conditions like generalized anxiety disorder, major depressive disorder, or post-traumatic stress disorder. While treatment of these disorders generally focuses on reducing reactivity to potentially threatening stimuli, there are in fact impairments across multiple domains including valence, arousal, and cognition. Here, we use the genetically stress-susceptible 129S1 mouse strain to explore the effects of stress across multiple domains. We find that 129S1 mice exhibit a potentiated neuroendocrine response across many environments and paradigms, and that this is associated with reduced exploration, neophobia, decreased novelty- and reward-seeking, and spatial learning and memory impairments. Taken together, our results suggest that the 129S1 strain may provide a useful model for elucidating mechanisms underlying myriad aspects of stress-linked psychiatric disorders as well as potential treatments that may ameliorate symptoms.
Anhedonia; CORT, corticosterone; Corticosterone; FED, Feeding Experimentation Device 3; FR, frequency-ratio 1; GR, glucocorticoid Receptor; Genetic background; Glucocorticoids; HPA, Hypothalamic-pituitary-adrenal; Learning; Memory; Motivation; PR, progressive-ratio; PTSD, post-traumatic stress disorder; RDoC, Research Domain Criteria; Stress
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Neurobiol Stress
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos