Anti-Inflammatory Effect of Mangiferin on an Experimental Model of Allergic Rhinitis through the Inhibition of NF-κB Signaling Pathways.
J Environ Pathol Toxicol Oncol
; 39(4): 357-364, 2020.
Article
en En
| MEDLINE
| ID: mdl-33389907
ABSTRACT
Allergic rhinitis (AR) is nasal inflammation caused by allergy and the prevalence of AR is rising globally. In this investigation, we used ovalbumin-provoked AR to examine the antiallergic, anti-inflammation activities of mangiferin. Mangiferin is a xanthone found in higher plants as well as mango and it has numerous health benefits including antitumor, antioxidant, antimutagenic, antidiabetic, antibacterial, and anti-inflammatory properties. Alternatively, the antiallergic action of mangiferin on AR has been not yet investigated. Mangiferin administration reduced the symptoms of nasal allergy such as sneezing as well as rubbing in AR. Besides, the generated MDA through allergen administration was considerably diminished as a result of mangiferin treatment. Additionally, mangiferin prevented the STAT3 as well as NF-κBp65 signaling pathway activation in the cytosol, which resulted in the anti-inflammatory cytokines being upregulated, whereas, the pro-inflammatory cytokines were downregulated. Moreover, mangiferin reduced signs of ciliary loss, vascular congestion in the lamina, goblet cell elevation, and eosinophil filtration in the AR model. Hence, our findings suggest that mangiferin is a promising approach for immunotherapy in AR disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xantonas
/
Factor de Transcripción ReIA
/
Rinitis Alérgica
/
Antiinflamatorios
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Environ Pathol Toxicol Oncol
Asunto de la revista:
NEOPLASIAS
/
PATOLOGIA
/
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China