Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis.
J Org Chem
; 86(4): 3334-3343, 2021 02 19.
Article
en En
| MEDLINE
| ID: mdl-33400871
ABSTRACT
A facile and versatile strategy employing TiCl4-mediated cyclization followed by a Cannizzaro reaction has been developed for the synthesis of various xanthene derivatives. The reaction proceeded smoothly to afford both xanthenes/xanthones or their sulfur derivatives and tolerated a wide range of electronically diverse substrates. Using this methodology, pranoprofen was synthesized in three steps in 59% overall yield from commercially available starting materials.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xantenos
/
Xantonas
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article