Interleukin-6 Blockade With Tocilizumab in Anakinra-Refractory Febrile Infection-Related Epilepsy Syndrome (FIRES).
Child Neurol Open
; 7: 2329048X20979253, 2020.
Article
en En
| MEDLINE
| ID: mdl-33403221
ABSTRACT
Febrile infection-related epilepsy syndrome (FIRES) is characterized by new onset refractory status epilepticus in a previously healthy child that is associated with poor cognitive outcomes and chronic epilepsy. Innate immune system dysfunction is hypothesized to be a key etiologic contributor, with a potential role for immunotherapy blocking pro-inflammatory cytokines, such as interleukin-1ß and interleukin-6. We present a case of FIRES refractory to anakinra, an interleukin-1 receptor antagonist, subsequently treated with the ketogenic diet and tocilizumab, an interleukin-6 receptor antagonist, temporally associated with seizure cessation and a favorable 1-year outcome.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Child Neurol Open
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos