Your browser doesn't support javascript.
loading
Neuronal fate acquisition and specification: time for a change.
Bonnefont, Jérôme; Vanderhaeghen, Pierre.
Afiliación
  • Bonnefont J; Université Libre de Bruxelles (U.L.B.), Institut de Recherches en Biologie Humaine et Moléculaire (IRIBHM), and ULB Neuroscience Institute (UNI), 1070 Brussels, Belgium; VIB-KULeuven Center for Brain & Disease Research, KULeuven Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium. Electronic address: jerome.bonnefont@ulb.ac.be.
  • Vanderhaeghen P; Université Libre de Bruxelles (U.L.B.), Institut de Recherches en Biologie Humaine et Moléculaire (IRIBHM), and ULB Neuroscience Institute (UNI), 1070 Brussels, Belgium; VIB-KULeuven Center for Brain & Disease Research, KULeuven Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium. Electronic address: pierre.vanderhaeghen@kuleuven.vib.be.
Curr Opin Neurobiol ; 66: 195-204, 2021 02.
Article en En | MEDLINE | ID: mdl-33412482
During embryonic development, neural stem/progenitor cells generate hundreds of different cell types through the combination of intrinsic and extrinsic cues. Recent data obtained in mouse and human cortical neurogenesis provide novel views about this interplay and how it evolves with time, whether during irreversible cell fate transitions that neural stem cells undergo to become neurons, or through gradual temporal changes of competence that lead to increased neuronal diversity from a common stem cell pool. In each case the temporal changes result from a dynamic balance between intracellular states and extracellular signalling factors. The underlying mechanisms are mostly conserved across species, but some display unique features in human corticogenesis, thereby linking temporal features of neurogenesis and human brain evolution.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células-Madre Neurales / Neuronas Límite: Animals Idioma: En Revista: Curr Opin Neurobiol Asunto de la revista: BIOLOGIA / NEUROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células-Madre Neurales / Neuronas Límite: Animals Idioma: En Revista: Curr Opin Neurobiol Asunto de la revista: BIOLOGIA / NEUROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido