Tune instead of destroy: How proteolysis keeps OXPHOS in shape.
Biochim Biophys Acta Bioenerg
; 1862(4): 148365, 2021 04 01.
Article
en En
| MEDLINE
| ID: mdl-33417924
ABSTRACT
Mitochondria are highly dynamic and stress-responsive organelles that are renewed, maintained and removed by a number of different mechanisms. Recent findings bring more evidence for the focused, defined, and regulatory function of the intramitochondrial proteases extending far beyond the traditional concepts of damage control and stress responses. Until recently, the macrodegradation processes, such as mitophagy, were promoted as the major regulator of OXPHOS remodelling and turnover. However, the spatiotemporal dynamics of the OXPHOS system can be greatly modulated by the intrinsic mitochondrial mechanisms acting apart from changes in the global mitochondrial dynamics. This, in turn, may substantially contribute to the shaping of the metabolic status of the cell.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
/
Proteínas Mitocondriales
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Proteolisis
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Mitofagia
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Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Bioenerg
Año:
2021
Tipo del documento:
Article