Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.

Pomella, Silvia; Sreenivas, Prethish; Gryder, Berkley E; Wang, Long; Milewski, David; Cassandri, Matteo; Baxi, Kunal; Hensch, Nicole R; Carcarino, Elena; Song, Young; Chou, Hsien-Chao; Yohe, Marielle E; Stanton, Benjamin Z; Amadio, Bruno; Caruana, Ignazio; De Stefanis, Cristiano; De Vito, Rita; Locatelli, Franco; Chen, Yidong; Chen, Eleanor Y; Houghton, Peter; Khan, Javed; Rota, Rossella; Ignatius, Myron S

Pomella, Silvia; Sreenivas, Prethish; Gryder, Berkley E; Wang, Long; Milewski, David; Cassandri, Matteo; Baxi, Kunal; Hensch, Nicole R; Carcarino, Elena; Song, Young; Chou, Hsien-Chao; Yohe, Marielle E; Stanton, Benjamin Z; Amadio, Bruno; Caruana, Ignazio; De Stefanis, Cristiano; De Vito, Rita; Locatelli, Franco; Chen, Yidong; Chen, Eleanor Y; Houghton, Peter; Khan, Javed; Rota, Rossella; Ignatius, Myron S.

Afiliación

Pomella S; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Sreenivas P; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Gryder BE; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Wang L; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Milewski D; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Cassandri M; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Baxi K; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Hensch NR; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Carcarino E; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Song Y; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Chou HC; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Yohe ME; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Stanton BZ; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Amadio B; Pediatric Oncology Branch, NCI, NIH, Bethesda, MD, USA.
Caruana I; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, 43205, USA.
De Stefanis C; SAFU Laboratory, Translational Research Area, Regina Elena National Cancer Institute, Rome, Italy.
De Vito R; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Locatelli F; Histology-Core Facility, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Chen Y; Department of Pathology Unit, Department of Laboratories, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Chen EY; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Houghton P; Departmentof Pediatrics, Sapienza University of Rome, Rome, Italy.
Khan J; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Rota R; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.
Ignatius MS; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.

Nat Commun ; 12(1): 192, 2021 01 08.

Article en En | MEDLINE | ID: mdl-33420019

Asunto(s)

Carcinogénesis/metabolismo; Diferenciación Celular; Proteína MioD/metabolismo; Proteínas de Fusión Oncogénica/metabolismo; Rabdomiosarcoma/genética; Rabdomiosarcoma/metabolismo; Factores de Transcripción de la Familia Snail/metabolismo; Animales; Carcinogénesis/genética; Diferenciación Celular/genética; Línea Celular Tumoral; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Femenino; Regulación Neoplásica de la Expresión Génica; Técnicas de Silenciamiento del Gen; Xenoinjertos; Humanos; Factores de Transcripción MEF2/metabolismo; Masculino; Ratones; Ratones SCID; Desarrollo de Músculos/genética; Proteína MioD/genética; Miogenina/metabolismo; Proteínas de Fusión Oncogénica/genética; Oncogenes; Rabdomiosarcoma/patología; Rabdomiosarcoma Alveolar/genética; Rabdomiosarcoma Embrionario/genética; Factores de Transcripción de la Familia Snail/genética; Transcriptoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabdomiosarcoma / Proteínas de Fusión Oncogénica / Diferenciación Celular / Proteína MioD / Carcinogénesis / Factores de Transcripción de la Familia Snail Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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