Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway.

Li, Xiang; Wang, Yuxin; Li, Liangping; Zhou, Shengji; Zhao, Fengchao

Li, Xiang; Wang, Yuxin; Li, Liangping; Zhou, Shengji; Zhao, Fengchao.

Afiliación

Li X; Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, People's Republic of China.
Wang Y; Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, People's Republic of China.
Li L; Department of Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, People's Republic of China.
Zhou S; Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, People's Republic of China.
Zhao F; Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, People's Republic of China. zhaofengchao@zju.edu.cn.

Cell Biol Toxicol ; 37(6): 849-871, 2021 12.

Article en En | MEDLINE | ID: mdl-33423118

Asunto(s)

Diterpenos; Ligando RANK; Animales; Diferenciación Celular; Proteína 61 Rica en Cisteína; Diterpenos/farmacología; Femenino; Ratones; Proteínas Quinasas Activadas por Mitógenos; FN-kappa B; Osteogénesis

Palabras clave

Cysteine-rich protein 61; Mitogen-activated protein kinase pathway; Osteoporosis; Receptor activator of nuclear factor-κB ligand; Sclareol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diterpenos / Ligando RANK Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Biol Toxicol Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Suiza

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