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Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction.
Louwe, Mieke C; Olsen, Maria B; Kaasbøll, Ole J; Yang, Kuan; Fosshaug, Linn E; Alfsnes, Katrine; Øgaard, Jonas D S; Rashidi, Azita; Skulberg, Vidar M; Yang, Mingyi; de Miranda Fonseca, Davi; Sharma, Animesh; Aronsen, Jan Magnus; Schrumpf, Elisabeth; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Nyman, Tuula A; Ueland, Thor; Melum, Espen; Halvorsen, Bente E; Bjørås, Magnar; Attramadal, Håvard; Sjaastad, Ivar; Aukrust, Pål; Yndestad, Arne.
Afiliación
  • Louwe MC; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Olsen MB; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Kaasbøll OJ; Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.
  • Yang K; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Fosshaug LE; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Alfsnes K; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Øgaard JDS; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Rashidi A; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Skulberg VM; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Yang M; Institute for Experimental Medical Research, Oslo University Hospital Ullevål, Oslo, Norway.
  • de Miranda Fonseca D; Department of Microbiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Sharma A; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway.
  • Aronsen JM; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway.
  • Schrumpf E; Institute for Experimental Medical Research, Oslo University Hospital Ullevål, Oslo, Norway.
  • Ahmed MS; Bjørknes College, Oslo, Norway.
  • Dahl CP; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Nyman TA; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Ueland T; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Melum E; Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.
  • Halvorsen BE; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Bjørås M; Department of Immunology, Institute of Clinical Medicine, University of Oslo and Rikshospitalet Oslo, Oslo, Norway.
  • Attramadal H; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Sjaastad I; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
  • Yndestad A; Faculty of Medicine, University of Oslo, Oslo, Norway.
JACC Basic Transl Sci ; 5(12): 1210-1224, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33426377
ABSTRACT
An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulated in wild-type mice receiving bone marrow from Nlrp3 -/- mice. This suggests that NLRP3 activation in hematopoietic cells infiltrating in the myocardium increases mortality and late ventricular remodeling. Our data should encourage performing clinical trials directly targeting NLRP3 inflammasome and their inflammatory cytokines (interleukin-1ß and -18) in MI patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2020 Tipo del documento: Article País de afiliación: Noruega
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2020 Tipo del documento: Article País de afiliación: Noruega