Helicobacter pylori Infection in Children with Concurrent Celiac Disease and Type 1 Diabetes Mellitus.
Dig Dis
; 39(5): 444-450, 2021.
Article
en En
| MEDLINE
| ID: mdl-33429389
ABSTRACT
OBJECTIVES:
Data regarding Helicobacter pylori (Hp) infection frequency in concurrent celiac disease (CD) and type 1 diabetes mellitus (T1DM) (CD + T1DM) are anecdotal. This study aimed to evaluate the association between Hp and concomitant CD + T1DM in children.METHODS:
In this 2-center, case-control study, children who underwent esophago-gastro-duodenoscopy (EGD) were studied. CD diagnosis was established by favorable histology and serology. Hp infection was confirmed by both histology and the rapid urease test. Patients were divided into 3 groups as CD only (CDo), CD + T1DM, and non-CD children who underwent endoscopy as controls.RESULTS:
Among the 1,431 EGDs performed, 783 cases were eligible. Overall, 215 cases had CDo (mean age 9.12 ± 4.18 years, 58.1% girls), 63 cases had CD + T1DM (mean age 9.29 ± 4.46 years, 50.8% girls), and 505 cases were controls (mean age 9.69 ± 4.52 years, 56.6% girls). Hp infection rate was significantly lower in CD + T1DM group (controls 49.7% vs. CDo 32.1% vs. CD + T1DM 20.6%, p < 0.01). After adjustment for age, gender, and socioeconomic status, the Hp infection rate was still significantly low (adjusted odds ratio [aOR] 1.57, 95% confidence interval (CI) 1.35-1.83, p < 0.01). A difference in Hp infection rate between controls and CDo group (aOR 1.43, 95% CI 1.09-2.12, p < 0.05), and between CDo and CD + T1DM (aOR 0.89, 95% CI 0.65-1.54, p < 0.05) group was significant. The severity of duodenal lesions and the presence of Hp infection were not correlated in all celiac children (r 0.113, p > 0.05).CONCLUSION:
The frequency of Hp infection was significantly lower in CD + T1DM children, compared to the CDo group and the controls.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Celíaca
/
Helicobacter pylori
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Infecciones por Helicobacter
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Diabetes Mellitus Tipo 1
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Dig Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2021
Tipo del documento:
Article