Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection.
J Immunol
; 206(4): 766-775, 2021 02 15.
Article
en En
| MEDLINE
| ID: mdl-33431657
ABSTRACT
Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Tnsf13 Reduced Tnfsf13 expression was associated with a profound defect in generating C. rodentium-specific IgA+ Ab-secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens, in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen-specific IgA+ Ab-secreting cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
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Inmunoglobulina A Secretora
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Transducción de Señal
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Citrobacter rodentium
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Infecciones por Enterobacteriaceae
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Receptores de Interleucina-17
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Mucosa Intestinal
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Immunol
Año:
2021
Tipo del documento:
Article