Small molecule targeting r(UGGAA)<sub>n</sub> disrupts RNA foci and alleviates disease phenotype in Drosophila model.

Shibata, Tomonori; Nagano, Konami; Ueyama, Morio; Ninomiya, Kensuke; Hirose, Tetsuro; Nagai, Yoshitaka; Ishikawa, Kinya; Kawai, Gota; Nakatani, Kazuhiko

Small molecule targeting r(UGGAA)_n disrupts RNA foci and alleviates disease phenotype in Drosophila model.

Shibata, Tomonori; Nagano, Konami; Ueyama, Morio; Ninomiya, Kensuke; Hirose, Tetsuro; Nagai, Yoshitaka; Ishikawa, Kinya; Kawai, Gota; Nakatani, Kazuhiko.

Afiliación

Shibata T; Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, Japan.
Nagano K; Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Chiba, Japan.
Ueyama M; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
Ninomiya K; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Hirose T; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Nagai Y; Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Ishikawa K; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
Kawai G; Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University, Tokyo, Japan.
Nakatani K; Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Chiba, Japan.

Nat Commun ; 12(1): 236, 2021 01 11.

Article en En | MEDLINE | ID: mdl-33431896

Asunto(s)

Drosophila/genética; ARN/genética; Animales; Secuencia de Bases; Núcleo Celular/metabolismo; Modelos Animales de Enfermedad; Células HeLa; Humanos; Intrones/genética; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Conformación de Ácido Nucleico; Fenotipo; Fosforilación; Proteínas de Unión al ARN/metabolismo; Bibliotecas de Moléculas Pequeñas/farmacología; Temperatura

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Drosophila Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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