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Non-genetic cell-surface modification with a self-assembling molecular glue.
Hakariya, Hayase; Takashima, Ippei; Takemoto, Misao; Noda, Naotaka; Sato, Shin-Ichi; Uesugi, Motonari.
Afiliación
  • Hakariya H; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp and Graduate School of Medicine, Kyoto University, Uji, Kyoto 611-0011, Japan and Training Program of Leaders for Integrated Medical System (LIMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japa
  • Takashima I; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp.
  • Takemoto M; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp.
  • Noda N; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp and Graduate School of Medicine, Kyoto University, Uji, Kyoto 611-0011, Japan.
  • Sato SI; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp.
  • Uesugi M; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. uesugi@scl.kyoto-u.ac.jp and Institute for Integrated Cell-Materials Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto 611-0011, Japan and School of Pharmacy, Fudan University, Shanghai 201203, China.
Chem Commun (Camb) ; 57(12): 1470-1473, 2021 Feb 15.
Article en En | MEDLINE | ID: mdl-33442714
ABSTRACT
This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article