Your browser doesn't support javascript.
loading
Occurrence and distribution of antimicrobial resistance genes in the soil of an industrial park in China: A metagenomics survey.
Zheng, Beiwen; Liu, Wenhong; Xu, Hao; Li, Junfeng; Jiang, Xiawei.
Afiliación
  • Zheng B; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • Liu W; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Xu H; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • Li J; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Jiang X; College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Electronic address: xiaweijiang@zcmu.edu.cn.
Environ Pollut ; 273: 116467, 2021 Jan 08.
Artículo en Inglés | MEDLINE | ID: mdl-33453699
ABSTRACT
As zoned areas of industries, industrial parks have great impacts on the environment. Several studies have demonstrated that chemical compounds and heavy metals released from industrial parks can contaminate soil, water, and air. However, as an emerging pollutant, antimicrobial resistance genes (ARGs) in industrial parks have not yet been investigated. Here, we collected soil samples from 35 sites in an industrial park in China and applied a metagenomics strategy to profile the ARGs and virulence factors (VFs). We further compared the relative abundance of ARGs between the sites (TZ_31-35) located in a beta-lactam antimicrobial-producing factory and other sites (TZ_1-30) in this industrial park. Metagenomic sequencing and assembly generated 14, 383, 065 contigs and 17, 631, 051 open reading frames (ORFs). Taxonomy annotation revealed Proteobacteria and Actinobacteria as the most abundant phylum and class, respectively. The 32 pathogenic bacterial genera listed in the virulence factor database (VFDB) were all identified from the soil metagenomes in this industrial park. In total, 685,354 ARGs (3.89% of the ORFs) and 272,694 virulence factors (VFs) (1.55% of the ORFs) were annotated. These ARGs exhibited resistance to several critically important antimicrobials, such as rifampins, fluroquinolones, and beta-lactams. In addition, no significant difference in the relative abundance of ARGs was observed between sites TZ_31-35 and TZ_1-30, indicating that ARGs have already disseminated widely in this industrial park. The present study gave us a better understanding of the whole picture of the resistome and virulome in the soil of the industrial park and suggested that we should treat the industrial park as a whole in the surveillance and maintenance of ARGs.
Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Environ Pollut Asunto de la revista: Salud Ambiental Año: 2021 Tipo del documento: Artículo País de afiliación: China

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Environ Pollut Asunto de la revista: Salud Ambiental Año: 2021 Tipo del documento: Artículo País de afiliación: China