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Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China.
Zhang, Jie; Ren, Yixuan; Pan, Liping; Yi, Junli; Guan, Tong; Yang, Xinyu; Zhang, Zongde.
Afiliación
  • Zhang J; Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Ren Y; Central Laboratory, Beijing Research Institute for Tuberculosis Control, Beijing, China.
  • Pan L; Central Laboratory, Beijing Research Institute for Tuberculosis Control, Beijing, China.
  • Yi J; Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Guan T; Central Laboratory, Beijing Research Institute for Tuberculosis Control, Beijing, China.
  • Yang X; Department of Tuberculosis, Huairou District Center for Diseases Control and Prevention, Beijing, China.
  • Zhang Z; Central Laboratory, Beijing Research Institute for Tuberculosis Control, Beijing, China.
J Int Med Res ; 49(1): 300060520984932, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33461383
ABSTRACT

OBJECTIVE:

This study analyzed drug resistance and mutations profiles in Mycobacterium tuberculosis isolates in a surveillance site in Huairou District, Beijing, China.

METHODS:

The proportion method was used to assess drug resistance profiles for four first-line and seven second-line anti-tuberculosis (TB) drugs. Molecular line probe assays were used for the rapid detection of resistance to rifampicin (RIF) and isoniazid (INH).

RESULTS:

Among 235 strains of M. tuberculosis, 79 (33.6%) isolates were resistant to one or more drugs. The isolates included 18 monoresistant (7.7%), 19 polyresistant (8.1%), 28 RIF-resistant (11.9%), 24 multidrug-resistant (MDR) (10.2%), 7 pre-extensively drug-resistant (XDR, 3.0%), and 2 XDR strains (0.9%). A higher rate of MDR-TB was detected among previously treated patients than among patients with newly diagnosed TB (34.5% vs. 6.8%). The majority (62.5%) of RIF-resistant isolates exhibited a mutation at S531L in the DNA-dependent RNA polymerase gene. Meanwhile, 62.9% of INH-resistant isolates carried a mutation at S315T1 in the katG gene.

CONCLUSION:

Our results confirmed the high rate of drug-resistant TB, especially MDR-TB, in Huairou District, Beijing, China. Therefore, detailed drug testing is crucial in the evaluation of MDR-TB treatment.
Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: Enfermedades Desatendidas Tema en salud: Tuberculosis Base de datos: MEDLINE Tipo de estudio: Estudio de tamizaje Idioma: Inglés Revista: J Int Med Res Año: 2021 Tipo del documento: Artículo País de afiliación: China

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Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: Enfermedades Desatendidas Tema en salud: Tuberculosis Base de datos: MEDLINE Tipo de estudio: Estudio de tamizaje Idioma: Inglés Revista: J Int Med Res Año: 2021 Tipo del documento: Artículo País de afiliación: China