Surface Grafted Antimicrobial Polymer Networks with High Abrasion Resistance.
ACS Biomater Sci Eng
; 2(7): 1169-1179, 2016 Jul 11.
Article
en En
| MEDLINE
| ID: mdl-33465875
ABSTRACT
In this work, we have investigated a quaternary ammonium compound that exhibits excellent antimicrobial activity and can be permanently grafted to substrates containing C-H bonds to form a durable polymeric film within 1 min. The compound consists of a biocidal component, dodecyl-alkylated quaternary ammonium, and a benzophenone moiety that, under mild UV irradiation, generates a densely cross-linked network and covalently attaches to a variety of substrates, including plastics, fabrics, and alkyl-modified glass surfaces. The surface attachment is 1 order of magnitude faster than that of previously reported benzophenone-associated cross-linkers, due to the electron-withdrawing effect of quaternary ammonium on the benzophenone chromophore. The modified surfaces are nonleaching and exhibit contact-killing and highly effective antimicrobial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) using cell count and live/dead staining methods. The charged ammonium group also promotes photoreaction efficiency with respect to network robustness, leading to a thin film that can sustain high shear forces and abrasion when compared to commercially available silane-based quaternary ammonium compounds. The biocidal activity is also retained after exposure to mechanical stress and abrasion.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
ACS Biomater Sci Eng
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos