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Effects of Different Continuous Aerobic Training Protocols in a Heterozygous Mouse Model of Niemann-Pick Type C Disease.
Cariati, Ida; Scimeca, Manuel; Tancredi, Virginia; D'Amico, Agata Grazia; Pallone, Gabriele; Palmieri, Mattia; Frank, Claudio; D'Arcangelo, Giovanna.
Afiliación
  • Cariati I; Medical-Surgical Biotechnologies and Translational Medicine, Department of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • Scimeca M; Department of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • Tancredi V; Department of System Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • D'Amico AG; Centre of Space Bio-medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • Pallone G; Department of Drug Science, University of Catania, 95125 Catania, Italy.
  • Palmieri M; Department of System Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • Frank C; Department of System Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • D'Arcangelo G; National Center for Rare Diseases, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy.
J Funct Morphol Kinesiol ; 5(3)2020 Jul 18.
Article en En | MEDLINE | ID: mdl-33467268
The positive effects of physical activity on cognitive functions are widely known. Aerobic training is known to promote the expression of neurotrophins, thus inducing an increase in the development and survival of neurons, as well as enhancing synaptic plasticity. Based on this evidence, in the present study, we analyze the effects of two different types of aerobic training, progressive continuous (PC) and varying continuous (VC), on synaptic and muscular plasticity in heterozygous mice carrying the genetic mutation for Niemann-Pick type C disease. We also analyze the effects on synaptic plasticity by extracellular recordings in vitro in mouse hippocampal slices, while the morphological structure of muscle tissue was studied by transmission electron microscopy. Our results show a modulation of synaptic plasticity that varies according to the type of training protocol used, and only the VC protocol administered twice a week, has a significantly positive effect on long-term potentiation. On the contrary, ultrastructural analysis of muscle tissue shows an improvement in cellular conditions in all trained mice. These results confirm the beneficial effects of exercise on quality of life, supporting the hypothesis that physical activity could represent an alternative therapeutic strategy for patients with Niemann-Pick type C disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Aspecto: Patient_preference Idioma: En Revista: J Funct Morphol Kinesiol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Aspecto: Patient_preference Idioma: En Revista: J Funct Morphol Kinesiol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza