Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases.
Br J Cancer
; 124(7): 1294-1300, 2021 03.
Article
en En
| MEDLINE
| ID: mdl-33473170
ABSTRACT
BACKGROUND:
Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer.METHODS:
One thousand two hundred and fifty patients with newly diagnosed brain metastases (BM) were identified from the Vienna Brain Metastasis Registry.RESULTS:
PLR and CRP/Alb were higher in patients with progressive extracranial disease and lower in patients with no evidence of extracranial disease. Lower NLR (cut-off = 5.07; 9.3 vs. 5.0 months), LLR (cut-off = 5.76; 10.0 vs. 5.3 months), PLR (cut-off = 335; 8.0 vs. 3.8 months), MLR (cut-off = 0.53; 6.0 vs. 3.5 months) and CRP/Alb (cut-off = 2.93; 8.5 vs. 3.7 months; padj < 0.05) were associated with longer overall survival (OS). In multivariate analysis with graded prognostic assessment (hazard ratio (HR) 1.45; 95% confidence interval (CI) 1.32-1.59; padj = 1.62e - 13), NLR (HR 1.55; 95% CI 1.38-1.75; padj = 1.92e - 11), LLR (HR 1.57; 95% CI 1.39-1.77; padj = 1.96e - 11), PLR (HR 1.60; 95% CI 1.39-1.85; padj = 2.87955e - 9), MLR (HR 1.41; 95% CI 1.14-1.75; padj = 0.027) and CRP/Alb (HR 1.83; 95% CI 1.54-2.18; padj = 2.73e - 10) remained independent factors associated with OS at BM diagnosis.CONCLUSIONS:
Systemic inflammation, measured by NLR, LLR, PLR, MLR and CRP/Alb, was associated with OS in patients with BM. Further exploration of immune modulating therapies is warranted in the setting of BM.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
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Neoplasias Encefálicas
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Linfocitos
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Biomarcadores de Tumor
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Mediadores de Inflamación
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Neoplasias
/
Neutrófilos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Año:
2021
Tipo del documento:
Article
País de afiliación:
Austria