Areas of Metabolomic Exploration for Helminth Infections.
ACS Infect Dis
; 7(2): 206-214, 2021 02 12.
Article
en En
| MEDLINE
| ID: mdl-33492932
ABSTRACT
Helminths represent a diverse category of parasitic organisms that can thrive within a host for years, if not decades, in the absence of treatment. As such, they must establish mechanisms to subsist off their hosts, evade the immune system, and develop a niche among the other cohabiting microbial communities. The complex interplay of biologically small molecules (collectively known as the metabolome) derived from, utilized by, or in response to the presence of helminths within a host is an emerging field of study. In this Perspective, we briefly summarize the current existing literature, categorize key host-pathogen-microbiome interfaces that could be studied in the context of the metabolome, and provide background on mass spectrometry-based metabolomic methodology. Overall, we hope to provide a comprehensive guide for utilizing metabolomics in the context of helminthic disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parásitos
/
Helmintiasis
/
Helmintos
Límite:
Animals
Idioma:
En
Revista:
ACS Infect Dis
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos