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Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus.
Bielefeld, Pascal; Abbink, Maralinde R; Davidson, Anna R; Reijner, Niels; Abiega, Oihane; Lucassen, Paul J; Korosi, Aniko; Fitzsimons, Carlos P.
Afiliación
  • Bielefeld P; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Abbink MR; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Davidson AR; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Reijner N; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Abiega O; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Lucassen PJ; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Korosi A; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Fitzsimons CP; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.
Stress ; 24(2): 189-195, 2021 03.
Article en En | MEDLINE | ID: mdl-33494651
LAY SUMMARYWe show for the first time, long-lasting effects of exposure to early life stress on cellular plasticity in the hypothalamus of adult mice.Stress in the first week of life resulted in reduced numbers of (proliferating) stem cells in specific subregions of the hypothalamus at an adult age.This loss of stem cells and decreased proliferation highlights how early life stress can affect hypothalamic functions in later life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Células-Madre Neurales Límite: Animals Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Células-Madre Neurales Límite: Animals Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido