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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White, Kris M; Rosales, Romel; Yildiz, Soner; Kehrer, Thomas; Miorin, Lisa; Moreno, Elena; Jangra, Sonia; Uccellini, Melissa B; Rathnasinghe, Raveen; Coughlan, Lynda; Martinez-Romero, Carles; Batra, Jyoti; Rojc, Ajda; Bouhaddou, Mehdi; Fabius, Jacqueline M; Obernier, Kirsten; Dejosez, Marion; Guillén, María José; Losada, Alejandro; Avilés, Pablo; Schotsaert, Michael; Zwaka, Thomas; Vignuzzi, Marco; Shokat, Kevan M; Krogan, Nevan J; García-Sastre, Adolfo.
Afiliación
  • White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kris.white@mssm.edu nevan.krogan@ucsf.edu adolfo.garcia-sastre@mssm.edu.
  • Rosales R; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Yildiz S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kehrer T; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Moreno E; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jangra S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Uccellini MB; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Coughlan L; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Martinez-Romero C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Batra J; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Rojc A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bouhaddou M; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fabius JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Obernier K; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Dejosez M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Guillén MJ; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Losada A; Department of Microbiology and Immunology and Center for Vaccine Development and Global Health (CVD), University of Maryland School of Medicine, Baltimore, MD, USA.
  • Avilés P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schotsaert M; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Zwaka T; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA 94158, USA.
  • Vignuzzi M; J. David Gladstone Institutes, San Francisco, CA 94158, USA.
  • Shokat KM; QBI Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.
  • Krogan NJ; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
  • García-Sastre A; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA 94158, USA.
Science ; 371(6532): 926-931, 2021 02 26.
Article en En | MEDLINE | ID: mdl-33495306
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Factor 1 de Elongación Peptídica / Depsipéptidos / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Factor 1 de Elongación Peptídica / Depsipéptidos / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos