Mediterranean diet and antihypertensive drug use: a randomized controlled trial.
J Hypertens
; 39(6): 1230-1237, 2021 06 01.
Article
en En
| MEDLINE
| ID: mdl-33496530
ABSTRACT
OBJECTIVE:
To examine in older individuals at high cardiovascular risk whether following a Mediterranean diet decreased the necessity of antihypertensive drugs and modulated their associated cardiovascular risk.METHODS:
In the PREvención con DIeta MEDiterránea study, we assessed whether volunteers randomly allocated to an intervention with a Mediterranean diet enriched with extra-virgin olive oil or nuts (relative to a low-fat control diet) disclosed differences in the risk of initiating antihypertensive medication in nonusers at baseline (nâ=â2188); and escalating therapy in participants using one, two, or three drugs at baseline (nâ=â2361, nâ=â1579, and nâ=â554, respectively). We also assessed whether allocation to Mediterranean diet modified the association between antihypertensive drug use and incident cardiovascular events.RESULTS:
Participants allocated to Mediterranean diet interventions were associated with lower risk of initiating antihypertensive therapy [5-year incidence rates 47.1% in the control diet, 43.0% in MedDiets; hazard ratioâ=â0.84, 95% CI (0.74--0.97), in a model adjusted for age, sex, and recruitment site]. Volunteers using two drugs at baseline in the Mediterranean diet intervention enriched with extra-virgin olive oil decreased their risk of therapy escalation [5-year incidence rates 22.9% in the control diet, 20.1% in the MedDiet; hazard ratioâ=â0.77, 95% CI (0.60--0.99)]. Allocation to Mediterranean diet interventions attenuated the association between antihypertensive therapy at baseline and incidence of major adverse cardiovascular events (P interactionâ=â0.003).CONCLUSION:
In an older population at high cardiovascular risk, following a Mediterranean diet reduced the risk of initiating or escalating antihypertensive medication and attenuated cardiovascular risk in antihypertensive drug users.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Dieta Mediterránea
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Humans
Idioma:
En
Revista:
J Hypertens
Año:
2021
Tipo del documento:
Article