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The CHRNA5 Polymorphism (rs16969968) and its Association with Waterpipe Smoking Addiction among Jordanians.
Al-Omoush, Thaka'a K; Alzoubi, Karem H; Khabour, Omar F; Alsheyab, Fawzi M; Abu-Siniyeh, Ahmed; Al-Sawalha, Nour A; Mayyas, Fadia A; Cobb, Caroline O; Eissenberg, Thomas.
Afiliación
  • Al-Omoush TK; Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan.
  • Alzoubi KH; Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Khabour OF; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
  • Alsheyab FM; Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan.
  • Abu-Siniyeh A; Department of Medical Laboratories, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
  • Al-Sawalha NA; Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Mayyas FA; Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Cobb CO; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
  • Eissenberg T; Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, VA, USA.
Arab J Basic Appl Sci ; 27(1): 450-455, 2020.
Article en En | MEDLINE | ID: mdl-33511332
ABSTRACT
Waterpipe smoking is a form of tobacco use that causes nicotine/tobacco dependence and has become a global health problem. In the current study, the association of rs16969968 SNP in the CHRNA5 gene with waterpipe dependence was investigated. A total of 386 men and women who used a waterpipe to smoke tobacco were recruited and divided into less dependent and more dependent smokers based on their score on the Lebanon Waterpipe Dependence Scale (LWDS). Results showed a significant difference in the distribution of GG, GA, and AA genotypes by waterpipe dependence status (P<0.001). The more dependent group showed a higher frequency of the AA genotype than the less dependent smokers' group (38% versus 23% respectively). In addition, the more dependent smokers exhibited more A allele than less dependent smokers (53% versus 37% respectively, P<0.001). In conclusion, there is an association between the rs16969968 SNP and waterpipe dependence as assessed by the LWDS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Arab J Basic Appl Sci Año: 2020 Tipo del documento: Article País de afiliación: Jordania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Arab J Basic Appl Sci Año: 2020 Tipo del documento: Article País de afiliación: Jordania