The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation.
Regen Med
; 16(1): 19-31, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33527839
ABSTRACT
Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim:
To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials &methods:
TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro.Results:
Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors.Conclusion:
Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Páncreas
/
Transdiferenciación Celular
Aspecto:
Determinantes_sociais_saude
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Middle aged
Idioma:
En
Revista:
Regen Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Rumanía