Interleukin-7-loaded oncolytic adenovirus improves CAR-T cell therapy for glioblastoma.

Huang, Jianhan; Zheng, Meijun; Zhang, Zongliang; Tang, Xin; Chen, Yaxing; Peng, Aijun; Peng, Xingchen; Tong, Aiping; Zhou, Liangxue

Huang, Jianhan; Zheng, Meijun; Zhang, Zongliang; Tang, Xin; Chen, Yaxing; Peng, Aijun; Peng, Xingchen; Tong, Aiping; Zhou, Liangxue.

Afiliación

Huang J; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Zheng M; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Zhang Z; State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Tang X; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Chen Y; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Peng A; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Peng X; State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Tong A; State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China. aipingtong@scu.edu.cn.
Zhou L; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China. liangxue_zhou@126.com.

Cancer Immunol Immunother ; 70(9): 2453-2465, 2021 Sep.

Article en En | MEDLINE | ID: mdl-33543339

Asunto(s)

Terapia Genética; Vectores Genéticos/genética; Inmunoterapia Adoptiva; Interleucina-7/genética; Viroterapia Oncolítica; Virus Oncolíticos/genética; Adenoviridae/genética; Animales; Apoptosis/genética; Apoptosis/inmunología; Antígenos B7/antagonistas & inhibidores; Antígenos B7/inmunología; Antígenos B7/metabolismo; Citocinas/metabolismo; Citotoxicidad Inmunológica; Modelos Animales de Enfermedad; Terapia Genética/métodos; Vectores Genéticos/administración & dosificación; Glioblastoma/etiología; Glioblastoma/metabolismo; Glioblastoma/patología; Glioblastoma/terapia; Humanos; Inmunofenotipificación; Inmunoterapia Adoptiva/métodos; Activación de Linfocitos/genética; Activación de Linfocitos/inmunología; Ratones; Viroterapia Oncolítica/métodos; Receptores de Antígenos de Linfocitos T/genética; Receptores de Antígenos de Linfocitos T/inmunología; Receptores Quiméricos de Antígenos/genética; Receptores Quiméricos de Antígenos/inmunología; Linfocitos T/inmunología; Linfocitos T/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

B7H3; CAR; Cancer; IL7; Oncolytic virus

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Inmunoterapia Adoptiva / Interleucina-7 / Virus Oncolíticos / Viroterapia Oncolítica / Vectores Genéticos Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Asunto de la revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Año: 2021 Tipo del documento: Article Pais de publicación: Alemania

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