Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells.

Madabhushi, Sri R; Podtelezhnikov, Alexei A; Murgolo, Nicholas; Xu, Sen; Lin, Henry

Madabhushi, Sri R; Podtelezhnikov, Alexei A; Murgolo, Nicholas; Xu, Sen; Lin, Henry.

Afiliación

Madabhushi SR; Biologics Upstream Process Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA. Electronic address: sri.madabhushi@merck.com.
Podtelezhnikov AA; Genetics and Pharmacogenomics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
Murgolo N; Genetics and Pharmacogenomics, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
Xu S; Biologics Upstream Process Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
Lin H; Biologics Upstream Process Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.

J Biotechnol ; 329: 92-103, 2021 Mar 10.

Article en En | MEDLINE | ID: mdl-33549674

Asunto(s)

Anticuerpos Monoclonales; Polisacáridos; Animales; Anticuerpos Monoclonales/metabolismo; Células CHO; Cricetinae; Cricetulus; Glicosilación

Palabras clave

B4Galt1; Galactosylation; Manganese; N-glycosylation; Specific productivity; Transcriptomics

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: J Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google