Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients.

Zhang, Yue; Han, Kai; Du, Chunjing; Li, Rui; Liu, Jingyuan; Zeng, Hui; Zhu, Liuluan; Li, Ang

Zhang, Yue; Han, Kai; Du, Chunjing; Li, Rui; Liu, Jingyuan; Zeng, Hui; Zhu, Liuluan; Li, Ang.

Afiliación

Zhang Y; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Han K; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Du C; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Li R; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Liu J; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Zeng H; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. zenghui@ccmu.edu.cn.
Zhu L; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. zhuliuluan@ccmu.edu.cn.
Li A; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. liang@ccmu.edu.cn.

Crit Care ; 25(1): 51, 2021 02 08.

Article en En | MEDLINE | ID: mdl-33557911

Asunto(s)

Anafilatoxinas/metabolismo; Tratamiento Farmacológico de COVID-19; COVID-19/inmunología; Carboxipeptidasa B/metabolismo; Carboxipeptidasa B/uso terapéutico; Trampas Extracelulares/efectos de los fármacos; Neutrófilos/efectos de los fármacos; Trombosis/prevención & control; Adulto; Anciano; COVID-19/fisiopatología; Trampas Extracelulares/inmunología; Femenino; Humanos; Masculino; Persona de Mediana Edad; Neutrófilos/inmunología; Trombosis/inmunología

Palabras clave

COVID-19; Carboxypeptidase B; Neutrophil extracellular trap; anaphylatoxin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Anafilatoxinas / Carboxipeptidasa B / Trampas Extracelulares / COVID-19 / Tratamiento Farmacológico de COVID-19 / Neutrófilos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Crit Care Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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