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Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening.
Handl, Jiri; Malinak, David; Capek, Jan; Andrys, Rudolf; Rousarova, Erika; Hauschke, Martina; Bruckova, Lenka; Cesla, Petr; Rousar, Tomas; Musilek, Kamil.
Afiliación
  • Handl J; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Malinak D; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
  • Capek J; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Andrys R; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
  • Rousarova E; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Hauschke M; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Bruckova L; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Cesla P; Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Rousar T; Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
  • Musilek K; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Chem Res Toxicol ; 34(3): 699-703, 2021 03 15.
Article en En | MEDLINE | ID: mdl-33566584
ABSTRACT
Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Reactivadores de la Colinesterasa / Riñón Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: República Checa
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Reactivadores de la Colinesterasa / Riñón Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: República Checa