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Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
Wilke, Julian; Kawamura, Tatsuro; Xu, Hao; Brause, Alexandra; Friese, Alexandra; Metz, Malte; Schepmann, Dirk; Wünsch, Bernhard; Artacho-Cordón, Antonia; Nieto, Francisco R; Watanabe, Nobumoto; Osada, Hiroyuki; Ziegler, Slava; Waldmann, Herbert.
Afiliación
  • Wilke J; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany; TU Dortmund University, Emil-Figge-Str. 72, 44221 Dortmund, Germany; RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Sai
  • Kawamura T; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany; RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Xu H; Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079, China.
  • Brause A; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
  • Friese A; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
  • Metz M; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
  • Schepmann D; Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstraße 48, 48149 Münster, Germany.
  • Wünsch B; Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstraße 48, 48149 Münster, Germany.
  • Artacho-Cordón A; Department of Pharmacology and Institute of Neuroscience, University of Granada, Avenida de la Investigación, 11, 18016 Granada, Spain.
  • Nieto FR; Department of Pharmacology and Institute of Neuroscience, University of Granada, Avenida de la Investigación, 11, 18016 Granada, Spain.
  • Watanabe N; RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Bio-Active Compounds Discovery Research Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Osada H; RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Ziegler S; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
  • Waldmann H; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany; TU Dortmund University, Emil-Figge-Str. 72, 44221 Dortmund, Germany. Electronic address: herbert.waldmann@mpi-dortmund.mpg.de.
Cell Chem Biol ; 28(6): 848-854.e5, 2021 06 17.
Article en En | MEDLINE | ID: mdl-33567254
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura / Receptores sigma / Proteoma / Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas / Compuestos Heterocíclicos con 2 Anillos / Compuestos de Anilina Límite: Animals / Female / Humans Idioma: En Revista: Cell Chem Biol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura / Receptores sigma / Proteoma / Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas / Compuestos Heterocíclicos con 2 Anillos / Compuestos de Anilina Límite: Animals / Female / Humans Idioma: En Revista: Cell Chem Biol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos