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Oxolipidomics profile in major depressive disorder: Comparing remitters and non-remitters to repetitive transcranial magnetic stimulation treatment.
Stirton, Hannah; Meek, Benjamin P; Edel, Andrea L; Solati, Zahra; Surendran, Arun; Aukema, Harold; Modirrousta, Mandana; Ravandi, Amir.
Afiliación
  • Stirton H; Cardiovascular Lipidomics Laboratory, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
  • Meek BP; Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Edel AL; Dept. of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Solati Z; Cardiovascular Lipidomics Laboratory, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
  • Surendran A; Cardiovascular Lipidomics Laboratory, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
  • Aukema H; Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Modirrousta M; Cardiovascular Lipidomics Laboratory, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
  • Ravandi A; Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
PLoS One ; 16(2): e0246592, 2021.
Article en En | MEDLINE | ID: mdl-33571313
ABSTRACT

BACKGROUND:

Repetitive Transcranial Magnetic Stimulation [rTMS] is increasingly being used to treat Major Depressive Disorder [MDD]. Given that not all patients respond to rTMS, it would be clinically useful to have reliable biomarkers that predict treatment response. Oxidized phosphatidylcholine [OxPC] and some oxylipins are important plasma biomarkers of oxidative stress and inflammation. Not only is depression associated with oxidative stress, but rTMS has been shown to have anti-oxidative effects.

OBJECTIVES:

To investigate whether plasma oxolipidomics profiles could predict treatment response in patients with treatment resistant MDD.

METHODS:

Fourty-eight patients undergoing rTMS treatment for MDD were recruited along with nine healthy control subjects. Plasma OxPCs and oxylipins were extracted and analyzed through high performance liquid chromatography coupled with mass spectrometry. Patients with a Hamilton Depression Rating Scale score [Ham-D] ≤7 post-treatment were defined as having entered remission.

RESULTS:

Fifty-seven OxPC and 32 oxylipin species were identified in our subjects. MDD patients who entered remission following rTMS had significantly higher pre-rTMS levels of total and fragmented OxPCs compared to non-remitters and controls [one-way ANOVA, p<0.05]. However, no significant changes in OxPC levels were found as a result of rTMS, regardless of treatment response [p>0.05]. No differences in plasma oxylipins were found between remitters and non-remitters at baseline.

CONCLUSION:

Certain categories of OxPCs may be useful predictive biomarkers for response to rTMS treatment in MDD. Given that elevated oxidized lipids may indicate higher levels of oxidative stress and inflammation in the brain, patients with this phenotype of depression may be more receptive to rTMS treatment.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Estrés Oxidativo / Trastorno Depresivo Mayor / Estimulación Magnética Transcraneal / Oxilipinas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Estrés Oxidativo / Trastorno Depresivo Mayor / Estimulación Magnética Transcraneal / Oxilipinas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Canadá