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PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
Sachamitr, Patty; Ho, Jolene C; Ciamponi, Felipe E; Ba-Alawi, Wail; Coutinho, Fiona J; Guilhamon, Paul; Kushida, Michelle M; Cavalli, Florence M G; Lee, Lilian; Rastegar, Naghmeh; Vu, Victoria; Sánchez-Osuna, María; Coulombe-Huntington, Jasmin; Kanshin, Evgeny; Whetstone, Heather; Durand, Mathieu; Thibault, Philippe; Hart, Kirsten; Mangos, Maria; Veyhl, Joseph; Chen, Wenjun; Tran, Nhat; Duong, Bang-Chi; Aman, Ahmed M; Che, Xinghui; Lan, Xiaoyang; Whitley, Owen; Zaslaver, Olga; Barsyte-Lovejoy, Dalia; Richards, Laura M; Restall, Ian; Caudy, Amy; Röst, Hannes L; Bonday, Zahid Quyoom; Bernstein, Mark; Das, Sunit; Cusimano, Michael D; Spears, Julian; Bader, Gary D; Pugh, Trevor J; Tyers, Mike; Lupien, Mathieu; Haibe-Kains, Benjamin; Artee Luchman, H; Weiss, Samuel; Massirer, Katlin B; Prinos, Panagiotis; Arrowsmith, Cheryl H; Dirks, Peter B.
Afiliación
  • Sachamitr P; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Ho JC; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Ciamponi FE; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Ba-Alawi W; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas, Brazil.
  • Coutinho FJ; The Structural Genomics Consortium, University of Campinas (UNICAMP), Campinas, Brazil.
  • Guilhamon P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Kushida MM; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Cavalli FMG; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Lee L; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Rastegar N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Vu V; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Sánchez-Osuna M; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Coulombe-Huntington J; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Kanshin E; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Whetstone H; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Durand M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Thibault P; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.
  • Hart K; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.
  • Mangos M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.
  • Veyhl J; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Chen W; RNomics Platform, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Tran N; RNomics Platform, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Duong BC; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Aman AM; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Che X; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Lan X; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Whitley O; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Zaslaver O; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Richards LM; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Restall I; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Caudy A; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Röst HL; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.
  • Bonday ZQ; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Bernstein M; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.
  • Das S; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Cusimano MD; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
  • Spears J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Bader GD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Pugh TJ; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Tyers M; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Lupien M; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada.
  • Haibe-Kains B; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.
  • Artee Luchman H; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Weiss S; Maple Flavored Solutions, LLC, Stony Brook, NY, USA.
  • Massirer KB; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.
  • Prinos P; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Arrowsmith CH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
  • Dirks PB; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Nat Commun ; 12(1): 979, 2021 02 12.
Article en En | MEDLINE | ID: mdl-33579912
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido