Neural markers of procrastination in white matter microstructures and networks.

ABSTRACT

More than 15% of adults suffer from pathological procrastination, which leads to substantial harm to their mental and psychiatric health. Our previous work demonstrated the role of three neuroanatomical networks as neural substrates of procrastination, but their potential interaction remains unknown. Three large-scale independent samples (total n = 901) were recruited. In sample A, tract-based spatial statistics (TBSS) and connectome-based graph-theoretical analysis was conducted to probe association between topological properties of white matter (WM) network and procrastination. In sample B, the above analysis was reproduced to demonstrate replicability. In sample C, machine learning models were built to predict individual procrastination. TBSS results showed a negative association between procrastination and WM integrity of limbic-prefrontal connection, and a positive relationship between intra-connection within the limbic system and procrastination. Also, both the efficiency and integrity of limbic WM network were found to be linked to procrastination. The above findings were all confirmed to replicate in an independent sample; prediction models demonstrated that these WM features can predict procrastination accurately in sample C. In conclusion, this study moves forward our understanding of procrastination by clarifying the role of interplay of self-control and emotional regulation with it.