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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Klein, Anders B; Nicolaisen, Trine S; Ørtenblad, Niels; Gejl, Kasper D; Jensen, Rasmus; Fritzen, Andreas M; Larsen, Emil L; Karstoft, Kristian; Poulsen, Henrik E; Morville, Thomas; Sahl, Ronni E; Helge, Jørn W; Lund, Jens; Falk, Sarah; Lyngbæk, Mark; Ellingsgaard, Helga; Pedersen, Bente K; Lu, Wei; Finan, Brian; Jørgensen, Sebastian B; Seeley, Randy J; Kleinert, Maximilian; Kiens, Bente; Richter, Erik A; Clemmensen, Christoffer.
Afiliación
  • Klein AB; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Nicolaisen TS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ørtenblad N; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Gejl KD; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
  • Jensen R; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
  • Fritzen AM; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
  • Larsen EL; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Karstoft K; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Poulsen HE; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Morville T; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Sahl RE; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Helge JW; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lund J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Falk S; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lyngbæk M; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ellingsgaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen BK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lu W; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Finan B; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Jørgensen SB; Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Seeley RJ; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
  • Kleinert M; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
  • Kiens B; Global Obesity and LD Research, Novo Nordisk A/S, Maaloev, Denmark.
  • Richter EA; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Clemmensen C; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Nat Commun ; 12(1): 1041, 2021 02 15.
Article en En | MEDLINE | ID: mdl-33589633
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Apetito / Resistencia Física / Ejercicio Físico / Receptores del Factor Neurotrófico Derivado de la Línea Celular Glial / Factor 15 de Diferenciación de Crecimiento / Conducta Alimentaria Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Apetito / Resistencia Física / Ejercicio Físico / Receptores del Factor Neurotrófico Derivado de la Línea Celular Glial / Factor 15 de Diferenciación de Crecimiento / Conducta Alimentaria Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido