Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer.
Adv Mater Interfaces
; 8(3)2021 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-33598379
ABSTRACT
2D nanomaterials have long been considered for development of high permeability membranes. However, current processes have yet to yield a viable membrane for practical use due to the lack of scalability and substantial performance improvements over existing membranes. Herein, an ultrathin graphene oxide (GO) membrane with a permeability of 1562 mL h-1 mmHg-1 m-2, two orders of magnitude higher than the existing nanofiltration membranes, and a tight molecular weight cut-off is presented. To build such a membrane, a new process involving self-assembly and optimization of GO nanoplatelet physicochemical properties is developed. The process produces a highly organized mosaic of nanoplatelets enabling ultra-high permeability and selectivity. An adjustable molecular interlinker between the layers enables absolute nanometer-scale size cut-offs. These characteristics promise significant improvements to many nanoparticle and biological separation applications. In this work, the performance of the membrane in blood dialysis scenarios is evaluated. Urea and cytochrome-c sieving coefficients of 0.5 and 0.4 are achieved while retaining 99% of albumin. Hemolysis, complement activation, and coagulation studies exhibit a performance on par or superior to the existing dialysis membrane materials.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Adv Mater Interfaces
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos